Trauma-induced coagulopathy: prospective observation study

Coagulopathy remains the leading cause of illness and death in people with severe trauma.
 The aim was to study indicators vascular-platelet hemostasis trauma establish changes main pathophysiological mechanisms primary that occur patients trauma-induced coagulopathy, compared almost healthy individuals same age.
 Materials methods. included 44 aged 19 55 years (36.1 [28.7; 43.2] years). control group 20 therapeutic department without preconditions for system, - 24 diagnosis “severe trauma” who were treated anesthesiology intensive care department.
 Results discussion. We studied intravascular platelet activation. Patients had a normal number platelets venous blood, but level spherocytes spheroechinocytes increased. On 3rd day after injury, blood normal, however discocytes decreased, discochinocytes, sum active forms fifth day, discochinocytes platelets, significantly higher (p<0.05) among group, spherocytes, involved aggregates, lower than (p<0.05).
 Conclusions. Indicators polytrauma significant differences from those group. This may be evidence activation system prerequisite late thrombotic complications